P21

cognitive-enhancement

Verified

A synthetic peptide fragment of activity-dependent neurotrophic factor (ADNF) with BDNF-like effects. It promotes neurogenesis in the hippocampus and has shown cognitive-enhancing properties in preclinical studies.

Chemical Information

Source:

Synthetic peptide fragment of activity-dependent neurotrophic protein (ADNP), modified for stability and blood-brain barrier penetration.

Clinical Information

Purposes:

Cognitive enhancement

Neurogenesis promotion

Memory improvement

Depression research

Alzheimer's research

Dosing:

Typical dosing is 500mcg-2mg daily via subcutaneous injection or intranasal administration.

Related Peptides:

Dihexa

Semax

BDNF

Safety Information

Side Effects:

Headache
Injection site reactions
Mild fatigue

Contraindications:

Pregnancy or breastfeeding
History of seizures
Psychiatric conditions

Research & References

Incerti M, et al. The synthetic peptide P21 promotes neurogenesis in the hippocampus and improves memory in mice. Neuropharmacology. 2013;76:76-83.
Gozes I, et al. Activity-dependent neurotrophic factor: intranasal administration of femtomolar-acting peptides improve performance in a water maze. J Pharmacol Exp Ther. 2000;293(3):1091-8.
https://pubmed.ncbi.nlm.nih.gov/24016753/

Last updated: 12/20/2025 at 12:19:12 AM

Version: 1

Detailed Information

Primary Uses