Dihexa

cognitive-enhancement

Verified

A potent nootropic peptide derived from angiotensin IV that acts on the hepatocyte growth factor (HGF) system. It demonstrates remarkable cognitive-enhancing effects in preclinical studies, being approximately 10 million times more potent than BDNF at promoting synaptogenesis.

Chemical Information

Source:

Synthetic hexapeptide analog of angiotensin IV. Chemical structure is N-hexanoic-Tyr-Ile-(6) aminohexanoic amide.

Clinical Information

Purposes:

Cognitive enhancement

Memory improvement

Synapse formation

Neuroprotection

Dementia research

Dosing:

Typical dosing is 10-20mg daily, administered orally or sublingually due to oral bioavailability.

Related Peptides:

Semax

Selank

P21

NSI-189

Safety Information

Side Effects:

Headache
Mild anxiety
Insomnia
Blood pressure changes

Contraindications:

Pregnancy or breastfeeding
Active cancer (due to HGF pathway involvement)
Cardiovascular disease

Research & References

McCoy AT, et al. Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents. J Pharmacol Exp Ther. 2013;344(1):141-54.
Benoist CC, et al. The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system. J Pharmacol Exp Ther. 2014;351(2):390-402.
https://pubmed.ncbi.nlm.nih.gov/23055539/

Last updated: 12/20/2025 at 12:19:12 AM

Version: 1

Detailed Information

Primary Uses